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How stressed tumor cells escape cell death: New mechanism discovered

How stressed tumor cells escape cell death: New mechanism discovered

Cancer cells are masters at evading cell death – a process that is crucial to the development and progression of tumors. Now, researchers have uncovered a new mechanism that allows stressed cancer cells to escape cell death.

The findings, published in the journal Cancer Cell, could lead to new therapeutic targets for treating cancer.

Cell death is a natural process that occurs when cells are damaged or no longer needed. It is an important part of maintaining tissue homeostasis and preventing the proliferation of damaged cells.

Cancer cells, however, are able to evade cell death through a variety of mechanisms. This allows them to continue to grow and spread, leading to the development of tumors.

Now, researchers have identified a new mechanism that allows stressed cancer cells to escape cell death. The findings could lead to new therapeutic targets for treating cancer.

The researchers found that cancer cells produce a protein called HSP47 that binds to collagen. This binding protects the cells from stress-induced cell death.

Inhibition of HSP47 activity sensitized cancer cells to stress-induced cell death. This suggests that HSP47 could be a potential target for therapeutic intervention.

The findings could lead to new ways to treat cancer, by targeting the mechanisms that allow cancer cells to evade cell death. Inhibition of HSP47 could provide a novel approach to cancer therapy.

Tumor cells are under constant stress from their environment, including nutrient deprivation, hypoxia, and DNA damage. This stress can trigger cell death, but tumor cells have evolved mechanisms to escape death and continue to grow.

Now, scientists have discovered a new mechanism that tumor cells use to escape cell death. The study, published in the journal Nature Cell Biology, found that tumor cells can remodel their mitochondria – the powerhouses of the cell – to escape cell death.

Previous research has shown that mitochondria are important in cell death. When a cell is stressed, damaged mitochondria release a protein called cytochrome c. This protein triggers a process called apoptosis, or programmed cell death.

However, the new study found that tumor cells can remodel their mitochondria to avoid releasing cytochrome c. The researchers used a technique called RNA sequencing to study the mitochondria of tumor cells under stress. They found that tumor cells change the way their mitochondria function in response to stress.

This change allows the tumor cells to avoid releasing cytochrome c, and escape cell death.

The findings could have important implications for cancer treatment. If we can understand how tumor cells escape cell death, we may be able to find new ways to kill them.

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