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‘Leaky’ activity of mutated enzyme underlies neurodegenerative disease

‘Leaky’ activity of mutated enzyme underlies neurodegenerative disease

Researchers from the University of Washington have found that a mutated enzyme causes a neurodegenerative disease by leaking out of cells. The enzyme, called TDP-43, is found in the brain and is responsible for breaking down proteins. However, when it is mutated, it begins to leak out of cells and accumulates in the brain. This accumulation leads to the death of nerve cells and the symptoms of the disease. The findings, published in the journal Nature, could lead to new treatments for the disease.

The researchers used a mouse model of the disease to study the effects of the mutated enzyme. They found that the mutant enzyme caused the death of nerve cells and the symptoms of the disease. The findings suggest that the mutant enzyme causes the disease by leaking out of cells and accumulating in the brain.

The findings could lead to new treatments for the disease. The researchers are currently working on a drug that could block the leaking of the mutated enzyme from cells.

In a new study, researchers have found that a mutated enzyme that is linked to neurodegenerative disease causes “leaky” activity in the brain.

This finding could lead to new treatments for neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease.

The mutated enzyme, called LRRK2, is known to be involved in neurodegenerative disease. However, the precise mechanism by which it causes disease has been unclear.

In the new study, the researchers used a technique called optogenetics to investigate the activity of LRRK2 in the brain. Optogenetics is a technique that allows researchers to control the activity of specific neurons with light.

The researchers found that LRRK2 causes “leaky” activity in the brain. This means that it causes neurons to fire when they should not be firing. This type of activity has been linked to neurodegenerative disease.

The findings of this study could lead to new treatments for neurodegenerative diseases. Currently, there are no effective treatments for these diseases.

The findings of this study were published in the journal Nature Neuroscience.

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