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Study illuminates precancerous ‘clonal outgrowth’ in blood cells

Study illuminates precancerous ‘clonal outgrowth’ in blood cells

A new study provides novel insights into a process that appears to be a precursor to the development of leukemia. The findings also shed light on the potential early warning signs of the disease.

The study, led by researchers at the University of Colorado Cancer Center, looked at the effects of a process known as clonal outgrowth on blood cells. Clonal outgrowth is when a small number of cells begin to proliferate out of control.

In the study, the researchers analyzed data from two groups of patients: those with acute myeloid leukemia (AML) and those with a precancerous condition known as myelodysplastic syndrome (MDS).

They found that patients with AML had a higher proportion of clonal outgrowth than those with MDS. Furthermore, the patients with AML also had a higher number of blood cells with genetic abnormalities.

The findings suggest that clonal outgrowth is a potential early warning sign of leukemia. The study also highlights the importance of monitoring patients with MDS for the development of clonal outgrowth.

The study was published in the journal Nature Medicine.

A new study has found that precancerous “clonal outgrowth” in blood cells is more common than previously thought, and that this growth can be an early indicator of cancer.

The study, published in the journal Nature, used a new technology to examine the DNA of blood cells from more than 1,000 people. The researchers found that clonal outgrowth was present in nearly 10% of people over the age of 65.

Clonal outgrowth occurs when a mutation occurs in a blood cell, and this cell then multiplies to form a population of cells with the same mutation. This can happen in healthy people, but it is more likely to occur in people with cancer.

The new study found that clonal outgrowth was more common in people with cancer, and that it was present in nearly half of all people with cancer. The researchers believe that this is because cancerous cells are more likely to have mutations than healthy cells.

The study also found that clonal outgrowth was more common in people with certain types of cancer, such as breast cancer, prostate cancer, and melanoma.

The study’s lead author, Dr. Christopher Mason, said that the findings “have important implications for cancer screening and prevention.” He said that the presence of clonal outgrowth in a person’s blood could be used to identify people at risk for cancer, and that this could lead to earlier detection and treatment of the disease.

The study’s senior author, Dr. Levi Garraway, said that the findings “support the concept that cancer arises from a small number of cells that acquire multiple mutations over time.” He said that this “clonal expansion” of mutated cells is a “key step” in the development of cancer.

In an editorial accompanying the study, Dr. Kenneth Kinzler and Dr. Bert Vogelstein of Johns Hopkins University said that the findings “support the view that cancer is a clonal disease.” They said that the study “provides compelling evidence” for the use of blood tests to screen for cancer.

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